Chapter 2: Table of Contents
Iodophors such as Povidone-iodine are used to kill bacteria, enveloped and some non-enveloped viruses, fungi, protozoa, and yeasts but have poor activity against spores. Povidone-iodine requires at least 2 minutes contact time to be effective. Iodophors kill by iodination and oxidation when free iodine is released. Iodophors may have persistent activity for several hours after use. Alcohol can increase the killing action of iodophors by liberating free iodine. Although iodophors have a broad spectrum and residual activity, they have drawbacks. Iodophors are corrosive to metals, making them a poor choice for sterilization of instruments, can be cytotoxic and can cause thyroid dysfunction with prolonged use. Povidone-iodine may also cause allergic responses in some individuals. Iodophors are inactivated by organic debris and will stain fabric and tissues.